Metformin與子宮內膜癌的檢視

The effects of metformin on endometrial cancer

Metformin是治療第II型糖尿病的主要藥物，最近亦被證明可用在許多癌症的預防與治療。在婦科，罹患第II型糖尿病的子宮內膜癌患者，metformin對治療是有幫助的；但是，對沒有糖尿病的子宮內膜患者是否具有相同功效，則有待更大規模的研究證實之。

Metformin (1, 1-dimethylbiguanide), frequently used in the treatment of type 2 diabetes, has been demonstrated to exert marked chemoprevention and antiproliferative effects against various types of cancer. In gynecologic oncology, metformin has been suggested to exhibit significant treatment efficacy against endometrial cancer in patients with type 2 diabetes. However, the most important question remains unanswered: Will metformin be effective against cancer in patients without diabetes? Further clinical and epidemiological studies are required to examine these issues.