有關於乳腺癌發生的危險因素之間的關係論述

An Overview on the Linkage between Risk Factors and Breast Cancer Development

乳腺癌是一個日益嚴重的公共健康問題。乳腺癌是一種異質性、多基因的疾病，根據組織學和基因組學特徵可分為不同的分子亞型。乳腺癌是一種具有多異質性的多基因疾病，發生的危險因素也一直是一個長期存在的假設。導致乳腺癌的發生的各種因素中，年齡和遺傳（家族背景）一直是長期以來所討論的焦點，雖然至今研究還未有證據證明應激性生活事件與罹患乳腺癌風險率有直接的關係。本文概述了這些危險因素與乳腺癌發生發展之間的關係。

Breast cancer is an increasing public health problem. Breast cancer is a heterogeneous and polygenic disease that can be divided into different molecular subtypes based on histological and genomic features. The influence of risk factors on the development and progression of breast cancer has been a long-standing hypothesis. Among the various factors which lead to the development of breast cancer, stress, age and genetic inheritance (family background) have always been the focal point of long and interminable discussions. Yet, studies have still not shown evidence to prove that there is a direct correlation between stressful life events and increased risk of breast cancer. This article provides an overview of the relationship between these risk factors and breast cancer development.