Early intervention is a group cooperative medical service. This article aims to illustrate the knowledge required by nurses who intend to practice in areas of early intervention. The contents consist of definitions, laws, and current practices in early intervention in Taiwan and the United States. In addition, the roles and responsibilities of nurses in transdisciplinary early intervention teams will also be introduced. This article will serve as an introduction for nurses practicing early intervention. We would also encourage the addition of the knowledge that it introduces to continuing education programs to enhance nurses' abilities in the screening and management of cases.