藥物食物不良反廳之資訊系統建構

An Information System to Prevent Adverse Drng-Food Interactions

臺灣醫療科技的進步使得民眾對於藥物產生了高度的依賴性。可是當人們服用藥物，除了藥物與藥物會有交互作用反應，在日常飲食中也具有與藥物會發生反應的食物，如此的反應或許會改變藥效也可能會對用藥者產生巨大的傷害。這個研究的目的有：(1)整理藥物與食物交互作用的公開文獻。(2)將食物名稱透過衛生署食材資料庫與特定食物類別作對應，來建構一個藥物與食物交互作用資料庫。(3)設計一個方便查詢的網頁。(4)利用手機簡訊，建構食品藥物資訊搜尋引擎，提供個人健康管理運用。本系統是使用電腦科技來幫助目前正在用藥物的大眾，使每個人都可以無慮的飲食，系統功能共有以網路介面呈現的「以單一食物查詢交互作用藥物」、「多筆藥物查詢交互作用食物」、「運用病歷資料之查詢」和「以手機簡訊之健康資訊搜尋」，以上功能搭配電子藥單，可以讓病人在用餐前便得到會與正在服用的藥物產生交互作用的食物列表，進而加以留意避免。希望藉此資訊系統，能避免讓藥物與食物的不良反應發生在用藥民眾，進一步提升用藥安全並讓藥品效力正確釋放。最後並以藥商資料及醫院臨床資料檢視在本系統裡藥物與食物之間交互作用發生的機率來進行評估。

With the progression and the convenience of medical environment in Taiwan, people have taken more and more medications to hope for improving their health. However, except for the well-known drug-drug interactions, there are foods that may cause food-drug interactions in our daily diet as well. Such interactions may not only reduce the pharmaceutical effects, but also cause serious damage to drag takers' health. Hence, how to prevent adverse drug-food interaction becomes an important and urgent work. The aims of this study are: (1) Investigate published drug-food interaction literatures. (2) Build the drug-food interaction database based on the food classification format published by the Department of Health (DOH) of Taiwan. (3) Create an easy-to-use web interface to query the database. (4) Create the short message service (SMS) query for mobile situations. The system we created in this study could be queried in four ways including 'drug interactions of single food', 'foods may interact with multiple drugs', 'prescriptions check', and 'search via mobile phone SMS' for personal health management. This system was evaluated by analyzing clinical data from pharmaceuticals and hospitals in Taiwan to find the exact food-drug interaction rates of most used drugs. In conclusion this system could reduce drug-food interactions, so that to raise drug efficiency, and to improve medication users' safety concerns.