冬蟲夏草對人體免疫反應之影響

Effect of Cordyceps sinensis on the immune modulation of normal human and compare between normal Cordyceps sinensis and synthesized Cordyceps sinensis

本實驗針對冬蟲夏草膠囊在人體內對於免疫反應抑制作用作研究。實驗徵求健康受試者以隨機雙盲方式分成實驗組及對照組，並給予冬蟲夏草膠囊（實驗組）及安慰劑（對照組）。實驗組冬蟲夏草劑量為1.5gm 一天兩次，服用三個月，於實驗前，服用一個月，兩個月及三個月各抽血檢驗嗜中性白血球吞噬率，PGE2，LTC4，及CD4-CD8比率。結果顯示嗜中性白血球吞噬作用、嗜中性白血球所產生PGE2在實驗組均有下降並有統計上差異。單核淋巴球治療前及治療後CD4及CD8的比值有偏向CD4的趨勢並且有統計上的意義。顯示冬蟲夏草菌絲體可經由抑制嗜中性白血球吞噬作用及抑制cyclooxygenase pathway，並調控CD4及CD8細胞數的比率，達到抗炎及免疫調節的作用。

Objective: The purpose of this study was to examine the immune modulatory effect of Cordyceps sinensis on the normal human. Methods: Thirty healthy volunteers were divided into nature Cordyceps Sinensis group, synthesized Cordyceps sinensis group and control group at random. The volunteers took medicine 500 mg /capsule three times per day for one month. Blood samples were collected from vein before and after taking medicine. Using an ultra-sensitive chemiluminescence analyzer and lucigenin amplification to detect free radical numbers. Results: After the administration of Cordyceps sinensis for one month, the free radical numbers decrease in both the nature Cordyceps sinensis group and synthesized Cordyceps sinensis group incompared with those in the control group (p< 0.05). Conclusion: Both the nature Cordyceps sinensis and synthesized Cordyceps sinensis could decrease the free radicals numbers of normal human after taking these medicines for one month .but the synthesized Cordyceps sinensis are more ecoamic and less expansive than the synthesized Cordyceps sinensis. In conclusion ,nature Cordyceps sinensis decrease normal human free radicals via immune modulation effect. Synthesized Cordyceps sinensis has the same effect as compare with nature Cordyceps sinensis. But the immune modulation mechanism of Cordyceps sinensis on normal human request further investigation.