雙相型疾患在類風濕性關節炎病人中相較正常人有較高的盛行率：統合分析研究

A Trend of Higher Prevalence of Bipolar Disorder in Patients with Rheumatoid Arthritis: A Preliminary Meta-analysis

目的：類風濕性關節炎是一種自體免疫疾病，且有數種致病因子被認為和雙相型疾患類 似，本統合分析研究探討類風濕性關節炎與雙相型疾患之間的共病率。方法：本研究藉由 電子搜尋資料庫 PubMed 的方式進行，所有關於探討類風濕性關節炎病人中雙相型疾患盛行 率的三篇文章都將被收錄進來。結果：研究發現雙相型疾患盛行率在類風濕性關節炎病人 中，顯著較其他沒有類風濕性關節炎的個案來得高（風險性＝ 1.491，95% 信賴區間＝ 1.049 - 2.119，p < 0.05）。結論：本研究點出類風濕性關節炎病人顯著有較高雙相型疾患盛行率， 希望研究者將來能著手進行探討兩者間可能共同存在之致病原因的研究。

Objective: The rheumatoid arthritis (RA) is an autoimmune disease and has been believed to share similar pathophysiology with bipolar disorder (BD). In this study, we intended to fi nd out the comorbidity rates between RA and BD thorough a meta-analysis of articles on their co-morbidity rate. Method: We did literature search through database of PubMed. Articles discussing the prevalence of BD in patients with/without RA were all included for meta-analysis. Results: Only three qualifi ed papers were chosen in this meta-analysis. We found that the prevalence of BD was signifi cantly higher in patients with RA than those without RA (odds ratio = 1.49, 95% confi dence interval = 1.049 - 2.119; p < 0.05). We did not fi nd that this study had any signifi cant heterogeneity or publication bias within the recruited three studies. Conclusion: The current study highlights the importance of higher prevalence of BD in patients with RA than those without RA. But further studies investigating the possible etiology and pathophysiology between them are encouraged.