Paliperidone Palmitate用於治療精神分裂症個案合併強迫症狀

Paliperidone Palmitate for Obsessive-compulsive Symptoms in a Patient with Schizophrenia: An Alternative Choice?

Mr. Chen, a 39-year-old male patient, was diagnosed with schizophrenia when he first admit-ted to our ward during June to August 2003 due to a cluster of disorganized symptoms including paranoid and reference delusion, self-talking, so-cial withdrawal, and aggressive behavior. Meanwhile, He also sustained some obsessive compulsive (OC) symptoms such as repetitive hand-washing, although those symptoms were improved after taking with risperidone. But dur-ing the next eight years due to his poor insight and drug incompliance, Mr. Chen had been admitted repeatly to our hospital for four times. Inspite that he accepted injection of risperidone (25 mg/2 weeks), zuclopenthixol (200 mg/2 weeks), and haloperidol (50 mg/2 weeks) as well as oral amis-ulpride (400 mg/day), his persecutory delusion, arguing with family and violence were persisted with little improvement. Besides, the ritual behav-iors recurred and occupied most of his time, in-cluding compulsive drinking, repeating lying and sitting up on bed, taking tissue paper for sneezing. Those OC symptoms were persisted even under the medication of serotonin specific reuptake in-hibitor (fluoxetine 40 mg/day). In January 2011, he received injection of paliperidone palmitate (150 mg initially, 1 week later 100 mg/month).