Trazodone在治療重度憂鬱症病人的療效是不如其他抗鬱劑

Trazodone Is Not as Effective as Other Antidepressants in Treating a Patient with Major Depressive Disorder

背景：Trazodone 在臨床使用上，會因其鎮靜及嗜睡的副作用而造成重度憂鬱症病人， 無法接受足夠的治療劑量。我們希望透過這篇案例報告，來闡述用trazodone 做抗憂鬱治 療的療效問題。個案報告：一位83 歲台灣男性罹患重度憂鬱症六個月的病人，一開始服用 trazadone（150 毫克／天）為期4 個月但療效不彰，隨即改為服用milnacipran （100 毫克／ 天）或mirtazapine（30 毫克／天），其治療效相當顯著。結論：提醒臺灣精神科醫師，應 慮該了解trazodone 在治療重度憂鬱症病人的療效，是不如其他抗鬱劑，不應該把trazodone 當成為重度憂鬱症病人的單一線抗憂鬱治療

Background: Trazodone in clinical use is ineffective because of its sedation to let patient receive an adequate dose for treating a patient with major depressive disorder. We are report a case report to demonstrate this clinical efficacy issue in the treatment with trazodone. Case Report: A 83-year old male Taiwanese patient had suffered from MDD for six months. He did not response to the treatment of trazodone 150 mg/day for four months, but consequently, he responded to the treatment of milnacipran 100 mg/day or mirtazapine 30 mg/day. Conclusion: Psychiatrists in Taiwan should be alert to the fact that trazodone is not as effective as other antidepressants, and that trazodone should not be prescribed as a single antidepressant in treating an MDD patient.