台灣關於第二代抗精神病劑之文章在國際性期刊的產量：一個書目計量研究

International Scientifi c Productivity on Second-generation Antipsychotic Drugs in Taiwan: A Bibliometric Study

背景：這是一個關於台灣發表與第二代（ 非典型）抗精神病劑(SGAs) 相關文章的書目 計量學研究。方法：利用EMBASE 及MEDLINE 資料庫，我們選擇了所有發表自台灣，內容 描述中包括非典型、抗精神病劑、SGAs、clozapine 等的文章。我們使用書目計量學中， 關於產量及離散性 (dispersion) 的指標，分別使用Price 定律，及Bradford 定律。我們同時 也計算了不同國家的參與度指數，並將部分台灣社會及健康資料與本書目計量學的研究結 果做相關性的研究。結果：我們下載了發表的359 篇與SGA 相關之原始文件。其中 29.53% 的文章與SGA 臨床療效有關，40.11% 的文章描述SGA 的副作用）。我們的研究結果符合 Price 定律，亦即與雙極性疾患有關的文章數呈現指數性的成長（ r = 0.960, 線性校正後r = 0.931 ）。SGA 最常被研究的藥物分別為clozapine (89)、risperidone (82)、aripiprazole (74)、olanzapine (62) 及quetiapine (22)。利用Bradford 定律的離散性分析得知，文章發 表多集中在Progress in Neuro-Psychopharmacology and Biological Psychiatry 期刊(56)。所有 來自台灣的文章發表在90 種不同期刊，而且在前10 名最常發表的期刊中，有8 種期刊的影 響係數(impact factor) 大於2。結論：台灣所發表的SGA 之文章數量，在本研究的期間內呈 現指數性的成長。

Background: This is a bibliometric study on the scientifi c papers of secondgeneration (atypical) antipsychotic drugs (SGAs) from Taiwan. Methods: With the EMBASE and MEDLINE databases, we chose the published documents from Taiwan with the descriptors of atypical*, antipsychotic*, second-generation antipsychotic*, clozapine, risperidone, olanzapine, ziprasidone, quetiapine, sertindole, aripiprazole, paliperidone, amisulpride, zotepine, asenapine, iloperidone and lurasidone. We used bibliometric indicators of production and dispersion, i.e., Price’s law on the increased scientifi c papers, and Bradford’s law on dispersion. We also calculated the participation index of the different countries, and correlated those bibliometric data with some social and health data from Taiwan (such as total per capita expenditure on health and overall volume of production in the fi eld of Psychiatry and Neurology). Results: We downloaded 359 SGA-related original documents published from 1993 to 2011: 29.53% of them were dealt with clinical effi cacy and 40.11% tolerance and safety. Our study results fulfi lled Price’s law, that scientifi c SGA papers showed exponential growth (r = 0.9601, as against an r = 0.9305 after linear adjustment). Of SGA publications, the drugs most studied are clozapine (89 papers), risperidone (82), aripiprazole (74), olanzapine (62), and quetiapine (22). Division of the results into Bradford zones yielded a nucleus published exclusively in the Progress in Neuro-Psychopharmacology and Biological Psychiatry (56 articles). All papers from Taiwan were published in 90 different journals, and 8 of the fi rst 10 most often published journals for Taiwanese papers have an impact factor being greater than 2. Conclusion: The published SGA papers from Taiwan have been growing exponentially from 1933-2011, without any evidence of reaching a saturation point.