Aripiprazole對亞斯柏格症患者刻板行為之療效

Aripiprazole for Stereotypical Behavior Patterns in Asperger’s Disorder

背景：過去研究支持，抗精神病藥物可以改善亞斯博格症患者的攻擊性，但少有文獻探討其對刻板行為的療效。在此報告以 ariPIPrazole 成功治療亞斯博格症患者刻板行為之一個案報告‘個案報告： 19 歲亞斯博格症男性，因動作遲緩及刻板化行為被帶來就醫，經 r 匕 peridone 、 haloperidol 、 olanzaPine 、 amisulpride 、 ziPrasidone 治療刻板化行為均無效。服用每日 10 nlg al ' iPipl ' az0le 後，個案的刻板化行為顯著減少，攻擊性亦消失。結論： ariPIPrazole 和其他抗精神病藥物對此個案的療效差異，可能與此藥對 D ：受器的部份致效性以及對 D ，受器的作用有關」詳細機制仍不清楚，。 riPiprazole 是否能治療亞斯博格症核心病理，需進一步研究。

Background: Previous research support the use of second-generation antipsychotic drugs to treat aggression in Asperger’s disorder (AD), but few studies have investigated their effi cacy in stereotypical behavior. This article reports the case of an AD patient whose stereotypical behaviors were improved signifi cantly following treatment with aripiprazole. Case Report: This 19-year-old male patient presented himself at hospital with severe psychomotor retardation and stereotypical behaviors. He received risperidone, haloperidol, olanzapine, amisulpride, and ziprasidone sequentially, but his stereotypical behaviors persisted. After treatment with aripiprazole at 10 mg per day, his stereotypical behaviors were signifi - cantly reduced and the aggression disappeared. Conclusion: In terms of dopamine pharmacological properties, aripiprazole and other antipsychotic agents differ mainly that aripiprazole is a partial dopamine agonist at D2 receptors and also acts on D3 receptors. The mechanism involved remains unclear, and the suitability of aripiprazole for treating the core pathophysiology of AD requires further investigation.