精神病患感染乙型肝炎病人之肝功能回顧性研究

Retrospective Evaluation of Liver Function in Psychiatric Patients with Hepatitis B Viral Infection

目的：臨床上常用valproic acid 治療極性疾患或其他精神疾病的病人，學理上病人如 果有肝功能異常的話，使用valproic acid 可能有潛在增加肝毒性副作用的風險。方法：我 們蒐集了623 位患有B 型肝炎的病人，依其使用valproic acid 的有無進行分析，以評估B 型肝炎病人暴露於valproic acid 下是否會有較高的肝功能指數。結果：我們發現這些B 型 肝炎抗原陽性的精神科住院病人，當使用valproic acid 治療時，肝功能指數並沒有顯著較 高。結論：研究發現在B 型肝炎病患身上使用valproic acid 對肝功能並未造成明顯的影響。

Background: Valproic acids are frequently used in patients with bipolar disorders or other psychiatric disorders. Safety issues have been concerned to prescribe valproic acid in patients with hepatic dysfunction due to its possible adverse effects of hepatotoxicity. Methods: We evaluated the values of SGOT and SGPT in 623 psychiatric inpatients who had hepatitis B infection and valproic acid through the computer database of a psychiatric hospital. Results: Psychiatric patients of hepatitis B carriers treated by valproic acid did not have higher levels of liver function compared to those who were not treated by valproic acid. Conclusion: The results of this study suggest that valproic acid use in psychiatric patients with hepatitis B infection is safe in terms of liver function.