血清中原肌球蛋白相關激酶B受體蛋白於肥胖重鬱症患者中增加

Increased Serum Tropomyosin-related Kinase B Protein Level in Obese Patients with Major Depressive Disorder

目的：腦源性神經營養因子(brain-derived neurotrophic factor, BDNF) 及其受體原肌 球蛋白相關激B 受體(tropomyosin-related kinase B, TrkB) 在情緒疾患中的地位已被探 討過。本研究試圖探討BDNF 及TrkB 的血中濃度在重鬱症病人中，與肥胖及自殺行為的關 聯。方法：BDNF 及TrkB 蛋白質濃度取自60 名門診及住院重鬱症病人的血清。身體質量指 數(body mass index, BMI) ≧ 26.4kg/m2 歸類為肥胖組。我們試圖區分肥胖／非肥胖及自殺 ／無自殺重鬱症病人間的關聯性。結果：我們發現BDNF 濃度在肥胖與非肥胖重鬱症病人 間以及自殺與未曾自殺的重鬱症患者間均無顯著差異。TrkB 濃度在肥胖重鬱症病人中顯著 上升(F = 4.137, p = 0.047)，但在自殺嘗試者與未曾自殺的重鬱症病人間則無顯著差異。 結論：我們的結果僅發現在重鬱症病人中，肥胖與TrkB 濃度有相關性，但仍需要更大的樣本 數的研究數據來證實這個發現。

Objectives: Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin- related kinase B (TrkB) protein have been previously associated with mood disorders. Here, we aimed to investigate the roles of BDNF and TrkB in suicidality and obesity in patients with major depressive disorder (MDD). Methods: The serum protein levels of BDNF and TrkB were determined in 60 MDD in- and outpatients. We classifi ed men and women with a body mass index (BMI) of ≧ 26.4 kg/m2 as obese. We examined the differences in serum BDNF and TrkB protein levels between obese/non-obese and suicidal/non-suicidal MDD patients. Results: We found no significant difference in serum BDNF protein levels between obese and non-obese MDD patients or between MDD patients with or without suicide history. The TrkB protein levels were found to be signifi cantly increased in obese MDD patients compared with those in non-obese MDD patients (F = 4.137, p = 0.047), but no signifi cant difference was found in the TrkB protein levels between MDD patients with and without suicide history. Conclusion: We found in this study that obesity in our study MDD patients was associated with increased serum TrkB levels. Increased TrkB levels may play a role in the pathophysiology of obese MDD patients.