以頻譜分析建構口腔癌小鼠舌診模型

A Novel Predictive Image Analysis of 4-nitroquinoline-1-oxideinduced Oral Cancer Mice by Using Fast Fourier Transform Function

口腔癌目前是受到重視的議題，科學家研發出以4-Nitroquinoline-1-oxide （4-NQO） 口腔癌模型，製造口腔癌小鼠（C57BL/6JNarl strain male） ，以更深入認識口腔癌。基於對口腔癌的關注，並考量目前缺乏非侵略性的診斷工具，本實驗將傅立葉（Fourier transform） 頻譜分析技術導入傳統中醫學理論（TCM theories），以建構簡易、再現性高，並且客觀的口腔癌動物舌診模型。實驗發現，隨著週數進展，腫瘤組和控制組的差異度愈來愈明顯。不同象限的舌象，也有顯出差異。在未來，可以用這個分析方式，對型態異常的舌象進行偵測篩檢，並且導入傳統中醫學理論，提供醫者更為客觀的依據。

Oral cancer has been a focus of great concern. Scientists have induced oral cancer in animals using the carcinogen 4-Nitroquinoline 1-oxide (4-NQO) to gain a deeper understanding of oral cancer. Considering the importance of oral cancer and the lack of noninvasive diagnostic techniques, this study proposed the integration of Fourier transform into Traditional Chinese Medicine (TCM) theories to establish a simple, repeatable, and objective tongue diagnosis model for oral cancer in animals. This study found that as the weeks progressed, differences between the tumor group and the control group became more pronounced. Different quarters of the tongue also showed significant differences. This screening method for oral cancer can be considered in the future, moreover, integrated into TCM to provide TCM physicians with information while making diagnoses.