噪音與二甲基甲醯胺在肌酸激酶效應上交互作用之探討

Effects of Noise and Dimethylformamide Exposure on Serum Creatine Kinase Levels

在過去，有關人造皮工廠工人血清中肌酸激酶值異常之情形，與有機溶劑二甲基甲醯胺之濃度是否有統計上之相關，並無定論。本研究為一橫斷性研究，將工作環境中之四種有機溶劑之濃度，列入危險因子中，在探制噪音暴露量之後，探討血清中肌酸激酶值異常之原因。 本研究以一家人造皮工廠之員工為對象，先進行勞工健檢，包括問卷及抽血檢驗血清中肌酸激酶值，而空氣中個人有機溶劑暴露濃度及噪音暴露量之測定，分別利用氣相層析儀連接火燄離子偵測器、以及必凱4436之噪音劑量計測定。由本研究中得到之肌酸激酶值異常率為13.7%，比起過去其它之研究降低許多，其中之原因可能為廠內環境之改善有關，或各研究中肌酸激酶值檢驗之儀器正常值相異，或血液貯存之條件不同所造成之結果。而由統計分析的結果得到，肌酸激酶值與廠內四種有機溶劑及噪音皆無相關，但此種情形亦有可能因為抽血時間之選擇與是否配戴防護具而影響了本研究之結果。

Studies of the associations of elevated serum creatine kinase (CK) levels and dimethylformamide (DMF) exposure among synthetic leather workers did not reach consistent conclusions. A cross-sectional study was conducted to elucidate the causes of the epidemic hyper CK emia with consideration of four organic solvents and noise exposure in workplace. Medical examination and serum CK levels determinations were performed in 293 worker of a synthetic leather factory. Air concentrations of solvents and noise exposure were measured with personal samplers and GC/FID and B&K 4436 Dose Meter, respectively, in 69 workers. The prevalence of elevated serum CK levels was 13.6%, lower than that of previous studies. The results showed no associations of serum CK levels with personal solvents and noise exposure. Further studies are recommended to note the effects of protective devices and timing of serum collection.