Meigs' syndrome is defined as the triad of benign ovarian tumor with ascites and pleural effusion that resolves after resection of the tumor. The ovarian tumor in Meigs' syndrome is a fibroma. No particular clinical symptoms but vague chief complaints such as fatigue, nonproductive cough, shortness of breath, abdominal bloating or weight loss is often encountered in the clinics of Family Medicine Department. After primary survey, mimics a malignant condition such as pelvic tumor, ascites, hydrothorax and elevated serum Carbohydrate Antigen-125 (CA-125) will be noted. But it is a benign disease with very good prognosis if properly managed. We report a case of Meigs' syndrome presented with nonproductive cough, shortness of breath, abdominal fullness and changed of bowel habit with tiny stool passaged as an initial manifestation. The purpose of this paper is to remind clinicans to consider Meigs' syndrome as a differential diagnosis of vague chief complaints of fatigue, nonproductive cough, shortness of breath, abdominal bloating or weight loss.