縲縈絲業員工CS[feaf]暴露與其他相關因子對尿中TTCA值關聯性之探討

The Relation of Carbon Disulfide Exposure and Other Workers' Factors to Urinary 2-Thiothiazolidine-4- Carboxylic Acid (TTCA) among the Workers in a Rayon Manufacturer

二硫化碳（Carbon disulfide, CS2）常用於縲縈絲製造業。文獻上指出暴露CS2對於神經、心血管與生殖系統會造成危害。尿中 2-thiothiazolidine-4-carboxylic acid（TTCA）為目前對 CS2 暴露評估上常用之生物指標。本研究的目的為探討作業員工 CS2 職業暴露程度是否會影響與尿中 TTCA 之關聯性，並對作業員工衛生習性、防護具佩戴與皮膚吸收因子等個人因素是否會影響 CS2 暴露與尿中 TTCA 之關係進行探討。本研究以台灣地區某一縲縈絲廠員工為對象，依 CS2空氣中作業測定結果分為高中低 CS2 三組職業暴露，收集工作 6 小時後之尿液進行 TTCA 之測定。其他個人影響因素則以問卷方式進行調查。本研究發現未校正之尿中 TTCA 測定值對於 CS2之職業暴露較肌酸酐校正之尿中 TTCA 較為敏銳。且在簡單迴歸分析中尿中 TTCA 分別與暴露程度、工作後是否淋浴、防護衣佩戴與否與洗手方式等個人因素達顯著統計相關。但在複迴歸分析中，僅未校正之尿中 TTCA 與暴露程度高低組別有顯著相關。顯示影響員工尿中 TTCA 值以暴露程度為主，且尿中 TTCA 僅可作為鑑別高與中低 CS2 暴露之指標，對於中低暴露則無法區別。

Carbon disulfide (CS2) is widely used in the rayon manufacturing industries. Neurological, cardiovascular, and reproductive manifestations resulting from the exposure to CS2 have been documented in the literature. 2-thiothiazolidine-4-carboxylic acid in urine (U-TTCA) has been widely used as a biomarker for occupational exposure to CS2. This study attempted to investigate whether fashion of the CS2 exposure to TTCA dose changes at different CS2 levels. This study also tried to investigate the influence of other personal factors like workers’ hygienic habit, use of personal protective equipment, and dermal absorption. The subjects, selected from a rayon-manufacturing factory in Taiwan, were classified as high, intermediate and low exposure groups based on environmental monitoring results. Spot urine was collected for each participant after at least six-hour, uninterrupted shift work. Data of other personal factors were collected by questionnaire. We found non-adjusted U-TTCA measurements are more sensitive than those by creatinineadjusted in the determination of occupational exposure to CS2. Moreover, CS2 levels measured under conditions such as immediate shower after work, wearing protective apron, and hand washing were significantly associated with U-TTCA in simple linear regression tests. However, CS2 level was the only variable positively associated with U-TTCA in multiple linear regression tests. We concluded that CS2 exposure level was the key factor affecting U-TTCA in workers. U-TTCA was indeed a bio-indicator capable of reflecting high/low CS2 exposure among workers, but might not be useful in of differentiating low exposure from intermediate exposure.