應用於生物感測器之恆電位儀電路與系統設計

Development of Potentiostat Circuit and System for Biomolecule Sensors

科技的進步帶來人類生活便利，生活習慣也隨之改變，導致現代文明病越來越多，包括心臟病、中風、阿茲海默症、糖尿病等，其中糖尿病的病患平時重點注意的是血糖，市面上大部分的血糖機需要採血量測，而這也是病患困擾的地方，量測時都要扎針，而本研究是一個免受扎針困擾的連續血糖偵測儀，藉由微針感測器偵測血糖，免扎針，透過無線傳輸即時傳到智慧裝置，讓使用者隨時隨地針對需求知道生理資訊，也可直接傳輸到雲端，送至家人端或醫療系統，使用者不用到醫院測血糖，醫生也可以了解病患的血糖狀況。大部分血糖的檢測方法是利用酵素與葡萄糖進行電化學反應，利用反應結果推斷血糖濃度，也有些是利用光學方法進行檢測。本文將介紹酵素的氧化還原反應、恆電位儀的設計原理以及信號處理。研究目標為研製連續檢測血糖儀，可隨時在智慧裝置得知血糖濃度，期望在未來可將此系統實現在居家照護系統。

This study presents a disposable continuous monitoring device consisting of microneedle electrodes for measuring glucose in interstitial fluid. Glucose oxidase was immobilized on the microneedle electrode utilizing an entrapment method. Signal processing was carried out using readout circuit. Data recording was transferred into the monitor by Bluetooth device. The results demonstrate that the reading values at various glucose concentrations were proportional to various concentrations of glucose in interstitial fluid. This technique eliminates pains in diabetes patients derived from lancing devices and is potential to detect not only glucose but also other metabolites for the purpose of healthy monitoring.