This study applies Watson's theory of human caring to investigate the nursing experiences of caring for a patient who had undergone long-term hemodialysis and whose disease and dialysis treatment had resulted This can affect their physical, mental and spiritual health. Between August 26, 2011 and September 19, 2011, the author collected data from observations, conversations, listening skills, physical assessment, medical history, and physical examinations for analysis to confirm that the health problems in this case were fatigue, body image disturbance, and hopelessness. The author applied ten caring elements from Watson's theory to the nursing process, using therapeutic communication skills to establish feelings of trust with the patient. These reliable methods were used to reduce fatigue, as well as physical and psychological discomfort. Continued care, accompaniment, empathy, and acceptance were used to encourage the patient to express inner feelings. Religious belief was enhanced to endow the patient with courage and energy to embrace life and reduce hopelessness. The aim of this nursing report is to increase recognition and understanding among clinical staff of the chronic fatigue symptoms of long-term hemodialysis patients. Using concrete and effective nursing measures to resolve the problems regarding nursing care for patients can improve the overall quality of life of patients.