In recent years, the health of people has been under the threat of ongoing chronic metabolic diseases. However, studies indicate that resveratrol has potential multi-bioactivity in hypoglycemic, prevention of cardiovascular disease, anti-cancer, and even life- prolonging, showing its advantage in fighting against chronic disease with an ideal effect. Chronic diseases are generally believed to be originating with excess body fat accumulation, whereas the fat cells will hinder the path of skeletal muscle cells to uptake sugar. Since skeletal muscle is the main place of the body to utilize glucose, its ability to effectively use or store energy of the body plays a very important role in the metabolic balance. For the past years there are few articles investigating physiological effects of resveratrol on skeletal muscle. Therefore, the purpose of this study is to investigate the specific physiological effects of resveratrol on skeletal muscle. Total illustration is divided into two parts, including the effects of resveratrol on energy metabolism of skeletal muscle, muscle remodeling and physical performance.