鐵調素在自體免疫疾病中之角色

The Role of Hepcidin in Autoimmune Diseases

前言：近年來鐵調素(hepcidin)被認為是體內鐵質，恆定的主要調節者與一種急性期蛋白，在鐵代謝疾病、炎症反應刺激下有可能導致hepcidin代謝的改變。因此本研究主要探討當發炎反應增加時，hepcidin濃度是否會就此上升。方法：收集的位自體免疫疾病患者作為實驗組，的位無任何肝、腎及代謝異常疾病者作為對照組，並以comp etitive ELISA方法分析hepcidin之濃度。結果：Hepcidin濃度在二組間並無差異，並與年齡(P＜0.0001)、Hb(P ＜0.0001)、monocyte (P =0.021)、creatinine(P =0.002)及ALT(P=0.009)等呈正相關性。結論：Hepcidin的調節與代謝會受到許多因子影響，能否作為評估發炎反應之因子仍有待進一步研究。

Introduction: Hepcidin is an acute-phase protein and has recently been considered as a major regulator of iron homeostasis in the body. Disorders of iron metabolism and inflammatory stimuli may result in changes in hepcidin metabolism. The purpose of this study was to determine if inflammatory responses may increase plasma hepcidin concentration. Methods: Eighty-five patients with autoimmune diseases were enrolled in experimental group and 85 healthy subjects were enrolled in control group. Plasma hepcidin concentrations were determined by ELISA method. Results: There was no difference in concentration of hepcidin between experimental and control groups, and there was a positive correlation between hepcindin and age, hemoglobin (Hb), monocyte, creatinine and alanine aminotransferase (ALT). Conclusion: The regulation and metabolism of hepcidin are affected by many factors. Whether hepcidin can be used as an evaluation factor of inflammation requires further studies.