胰臟β細胞功能評估之介紹

Introduction of Pancreaticβ-cell Function Assessment

糖尿病致病機轉之一，即為β細胞分分泌胰島素不足。而β細胞功能的參數亦可間接作為評估糖尿病病程進展及預測糖尿病的發生，並提供臨床醫生輔以作為治療糖尿病之成效指標。因此，如何評估β細胞功能，為一重要臨床課題。目前有許多方法可以測量β細胞功能，由簡單容易操作的，到較為複雜需要特殊方法的，各有各的優缺點。其中以口服葡萄糖測量為基礎之β細胞功能的定量數學模式，算是既簡單又不失準確的方法。本文將介紹血糖調控機制及姨臟β細胞功能指標與測量方式，以提供糖尿病相關研究及臨床運用之參考。The Pathogenesis of Diabetes is lack of insulin secretion. Meanwhile, those parameters of β-cell function can also be used to diagnose diabetes and assess the progression of diabetes. Therefore, it provides clinicians as the performance indicators for diabetes treatment. Furthermore, it also provides the evidence for the effectiveness of clinic treatment. The measurement of β-cell function is a critical clinical issue. There are many methods to measure β-cell function from simple operation to complicated one which have their own advantages and disadvantages. The oral glucose tolerance test (OGTT) based on the simple quantitative mathematical model can be regarded as an accurate method, and it also contributes to safety and convenience. The purpose of this article will introduce regulatory mechanism of blood glucose and bio-physiologic measurements methods and procedure of pancreatic β-cell function in order to provide the references for researchers and clinicians.