聖愈湯改善環己醯胺誘發大鼠之健忘

Effects of San-Yu-Tang on the Cycloheximide-Induced Amnesia in Rats

本研究以被動迴避學習反應儀探討聖愈湯對環己醯胺誘發大鼠健忘之影響。結果顯示，每天口服聖愈湯0.5 或1.0 g/kg 一次，連續給予一星期，可顯著延長健忘動物被動迴避反應期，聖愈湯改善環己醯胺誘發大鼠之健忘可被8-OH-DPAT （5-HT1A 部份致效劑）增強；但被SCOP （蕈毒鹼拮抗劑）、PCA （5-HT 釋放劑）及BAC （GABA-B 接受器拮抗劑）減弱。綜合以上結果顯示，聖愈湯增強健忘大鼠的記憶功能可能與增強蕈毒鹼接受器及GABA-B 接受器活性及降低5-HT 系統活性有關。The effects of San-Yu-Tang (SYT) on cycloheximide (CXM)-induced amnesia were assessed by passive avoidance in rats. Oral SYT administration (0.5 or 1 g/kg for 1 week) significantly prolonged step-through latency in the amnesic animals. This beneficial effect of SYT on CXM-induced amnesia was enhanced by 8-OH-DPAT (a partial agonist of the 5-HT1A receptor), but reduced by scopolamine (a muscarinic antagonist) and p-chloroamphetamine (a 5-HT releaser) and baclofen (a GAGAB receptor antagonist). These results suggest that SYT enhances memory functions in amnesic rats, at least in part, by increasing the activity of the muscarinic and GABAB receptors, and decreasing the activity of the serotoninergic system.