台灣金線連減弱東莨菪鹼誘發健忘作用

Anoectochilus Formosanus Attenuates Amnesia Induced by Scopolamine in Rats

本研究以被動迴避學習反應儀探討台灣金線連水抽出物（簡稱AFW ）對東莨菪鹼誘發健忘之作用，結果顯示AFW 在l.0 及2.0 公克/ 公斤劑量可改善東莨菪鹼誘發之健忘，AFW 之抗健忘作用可被週邊膽鹼毒菌鹼接受器拮抗劑scopolamine N-methylbromide 所拮抗，並會被neostigmine 及physostigmine 增強。綜合以上結果顯示AFW 抗東莨菪鹼誘發之健忘作用與增強全身膽鹼神經系統活性有關。The effect of the water extract of Anoectochilus formosanus (AFW) on SCOP-induced amnesia was investigated in a step-through passive avoidance task in rats. It was observed that AFW at the doses of 1.0 and 2.0 g/kg attenuated SCOP-induced amnesia. The anti-amnesic effect of AFW on the SCOP-induced amnesia was significantly reversed by a peripheral cholinergic muscarinic receptor antagonist, SCOP N-methylbromide and augumented by neostigmine and physostigmine. These results suggest that the anti-amnesic effect of AFW on SCOP-induced amnesia may be related to the increase in the systematic cholinergic neuronal system activity.