| 中文摘要 |
壓瘡的形成與缺血及缺血後再灌流所產生的自由基有密切的關係。我們在先前的臨床研究中發現生肌散對於壓瘡確有促進癒合的效果，為求進一步了解其可能的有效作用機轉，吾等著手探討生肌散清除相關自由基的作用。結果顯示：生肌散對於Xanthine / Xanthine oxidase 所產生之超氧陰離子有明顯的清除作用，對於FeCl2 所誘發的脂質過氧化作用也有明顯的抑制效果。兒茶對於人體白血球產生超氧陰離子、過氧化氫與次氯酸有明顯的抑制作用。生肌散與其組成藥物兒茶有助於減少缺血後再灌流所產生的自由基對組織的損傷。理論上生肌散應該有利於壓瘡傷口的癒合。但是生肌散對於激發態的白血球所產生的過氧化氫、次氯酸與超氧陰離子卻不具抑制作用，其原因則值得進一步探討。SHENG-JI-SAN promotes the healing of pressure ulcers successfully in our clinical research. According to the correlationship between ischemia, post-ischemic reperfusion injury and the pressure ulcers, we tried to investigate the anti-oxidative effect of SJS. The result showed that SJS effectively scavenge the superoxide anion produced by Xanthine/ Xanthine oxidase and also inhibit the lipid peroxidation induced by ferrous chloride. Acacia catechu inhibit hydroperoxide, hypochloride and superoxide produced by stimulated human white cells. It’s contributory to understanding the mechanism of SJS to accelerate the healing of pressure ulcers. |
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