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篇名
樟芝菌株(CCRC 93032)發酵液對大鼠28天餵食的毒性作用
並列篇名
EFFECTS OF 28-DAYS’ REPEATED ORAL ADMINISTRATION OF THE FERMENTED EXTRACT OF MYCELIA OF ANTRODIA COMPHORATA (CCRC 93032) ON RATS
作者 林文川郭淑卿吳岳文
中文摘要
本實驗主要探討樟芝菌株發酵濃縮液連續經口投予28 天對雌、雄大鼠的毒性。樟芝菌株發酵濃縮液的劑量為每天投予1 、2 或3 g/kg 。血液學檢查:雄鼠3 g/kg 組出現平均紅血球容積和平均紅血球血色素量降低的情形。血清生化學檢查:雄鼠3 g/kg 組血中總蛋白質、葡萄糖、磷濃度及乳酸去氫 活性增加,雄鼠 2 、 3 g/kg 組和雌鼠3 g/kg 組的血中鉀離子濃度明顯下降。尿液分析:雄和雌鼠2 、3 g/kg 組的尿中排出的鈉和氯離子量增加,雄和雌鼠3 g/kg 組出現尿蛋白的隻數增加。雄鼠3 g/kg 組肝臟及腎臟的相對重量增加,但並無實質上的病理組織變化。大鼠連續投予樟芝菌株發酵濃縮液,安全劑量在2 g/kg 以下。Toxicity study was carried out by administering orally daily doses of 1, 2 and 3 g/kg of the fermented extract of mycelia of Antrodia camphorata (FEMAC) to groups of male and female rats for 28 days. Hematological analyses indicated that male rats given 3 g/kg showed significant decreases in mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH). Serum biochemical profiles indicated increased levels of total protein, glucose, phosphorus and activities of lactate dehydrogenase (LDH) were observed in male rats of the 3 g/kg group while decreased serum potassium was observed in male rats given 2 or 3 g/kg as well as female rats given 3 g/kg. Urinalyses showed increased levels in both sodium and chloride ions in both male and female rats of the 2 and 3 g/kg groups, increased incidence of proteinuria in the 3 g/kg groups of both sexes and increase in relative weights of the liver and kidneys in male rats given 3 g/kg although no accompanying histopathological changes were observed. In conclusion, the safety dose of fermented extract of mycelia of Antrodia camphorata (FEMAC) in rats following 28 days of oral administration appeared to be below 2 g/kg.
起訖頁 293-303
關鍵詞 板藍根顯微鑑別馬藍野木藍大青菘藍 Ban-Lan-GenMicroscopic identificationStrobilanthes cusia Indigofera suffruticosa Clerodendrum cyrtophyllum Isatis indigotica
刊名 中醫藥雜誌  
期數 200112 (12:4期)
出版單位 衛生福利部國家中醫藥研究所(原:國立中國醫藥研究所)
該期刊-上一篇 腦中風中西醫診斷類型之相關性研究--八十五例分析
 

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