| 中文摘要 |
針灸是一個歷史悠久的方法，可用來治療疾病和舒解疼痛。在東方國家，針灸使用在治療心血管、呼吸、內分泌、消化系統疾病已有好幾世紀的時間。相似地，在西方國家利用神經肌肉電刺激來緩解疼痛、增加肌力、提高週邊血管病變病人的血流量。近年來也有一些利用表面電極來電刺激穴位的方法，此方法也可以產生和針刺、電針相同的生理及治療效果，尤其應用在治療周邊血管病變。目前，對於傳統針刺、電針、神經肌肉電刺激應用在治療腦病變方面仍頗多爭議。為了瞭解針刺和腦中神經傳遞物質釋放之間的相關性，本篇研究報導利用微透析探針插入腦中的某些特定區來偵測該區域神經傳遞物質的釋放。在這個新的研究領域，本論文提供了一些詳細的微透析研究步驟及方法。Acupuncture has been used in the treatment of diseases and relief of pain for centuries in The Orient. Acupuncture may be effective in the management of patients with compromised cardiovascular, respiratory, endocrine and digestive function. Similarly, neuromuscular electrical stimulation has been commonly employed in Western countries to alleviate pain, augment muscle strength and enhance blood flow in clinic applications, particularly as adjunctive treatment for peripheral vascular diseases. In the same way, electrical stimulation of acupuncture points with skin plate electrodes can elicit the same physiological and therapeutic effects as those produced by acupuncture and electro-acupuncture techniques, most commonly in connection with treatment of with peripheral vascular disease. Recently, there are controversies in the literature as to the effects of traditional acupuncture, electro-acupuncture and neuromuscular electrical stimulation in the treatments on brain disease. In order to investigate the relationship between acupuncture and brain neurotransmitter disposition, the microdialysis technique, which involved the inserting into a specific brain region of an animal dialysis probe through which neurotransmitter levels could be continuously monitored, was employed. This paper provides the details of such an acupuncturemicrodialysis model, and discussion of the advantages and limitations of such approach. |
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