薑黃素於兔體中對茶鹼動態學之影響

Effect of Curcumin on Theophylline Pharmacokinetics in Rabbits

茶鹼（Theophylline ）為一臨床常用之氣管擴張劑，其治療指數狹窄，主要由CYP1A2 代謝。薑黃素（Curcumin ）為一具有多種優越活性的天然多酚化合物，對CYP1A2 具強力的抑制作用。本研究探討薑黃素在兔體內對茶鹼動態學之影響。結果顯示薑黃素僅增加其吸收半生期，而對其他的藥物動力學參數沒有顯著之影響。因此併服薑黃素會延緩茶鹼生效，但應不會導致茶鹼急性中毒。Theophylline is a widely used bronchodilator with narrow therapeutic index and undergoes extensive metabolism by CYP1A2. Curcumin is a natural polyphenol with various beneficial biological activities and was shown to be a potent inhibitor of CYP1A2. The purpose of this study was to investigate the effect of curcumin on the pharmacokinetics of theophylline in rabbits. The result showed that curcumin only significantly increased the absorption half-life of theophylline from 0.20 ± 0.02 h to 0.36 ± 0.05 h, other pharmacokinetic parameters were not affected. It indicated that coadministration of curcumin delayed the onset of theophylline but would not result in the acute intoxication of theophylline.