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篇名
闊葉大豆(金門產一條根)水粗萃取物對大鼠28天餵食毒性作用
並列篇名
EFFECTS OF 28-DAY’S REPEATED ORAL ADMINISTRATION OF CRUDE AQUEOUS EXTRACTS OF GLYCINE TOMENTELLA HAYATA ON RATS
作者 林文川柯裕仁吳岳文
中文摘要
本實驗主要探討闊葉大豆(金門產一條根)水粗萃取物連續經口投予28 天對雌、雄大鼠的毒性。闊葉大豆水粗萃取物的劑量為每天投予1 、2 或3 g/kg 。血液學檢查:雌鼠3 g/kg 組出現平均紅血球容積增加的情形。血清生化學檢查:雌鼠3 g/kg 組血中鈉、鉀離子濃度及麩氨酸草乙酸轉氨 活性增加,但總膽固醇、總蛋白,白蛋白、球蛋白、總膽紅素、肌酸酣及鎂離子濃度降低。雌鼠2 g/kg 組也出現總膽紅素及鎂離子濃度下降的情形。尿液分析:雄鼠與雌鼠3 g/kg 組尿液鉀璃子量增加,雌鼠3 g/kg 組蛋白尿增加。雄鼠3 g/kg 組精囊重量萎縮,但並無實質上的病理組織變化。大鼠連續投予討闊葉大豆水粗萃取,安全劑量在2 g/kg 以下。Toxicity study was carried out by administration orally daily doses of 0, 1, 2 and 3 g/kg of crude aqueous extracts of Glycine tomentella Hayata (GTE) to groups of male and female rats for 28 days. In hematology, female rats given 3 g/kg showed an increase in mean corpuscular volume (MCV). In blood chemistry, an increased levels of sodium, potassium and activities of glutamic oxalacetic transaminase (GOT) were observed in female rats of 3 g/kg dose group. Female rats given 3 g/kg showed a decrease in concentration of total cholesterol, total protein, albumin, gloublin, total bilirubin and magnesium. Female rats given 2 g/kg also showed a decrease in concentration of total bilirubin and magnesium. Urinalysis showed an increase in Na+ level in both male and female rats of 3 g/kg dose group. Increased urinary protein was observed in female rats of the 3 g/kg dose group. Male rats given 3 g/kg showed an increase seminal vesicle weight. However, no accompanying histopathological changes were observed. In conclusion, the toxicological noobserved levels in rats were thought to be 2 g/kg or below.
起訖頁 205-215
關鍵詞 藥膳生脈鰱魚調節血脂抗氧化延緩衰老 Medicinal mealShenmailianyu Blood-lipid regulationAntioxidationAntiaging
刊名 中醫藥雜誌  
期數 200012 (11:4期)
出版單位 衛生福利部國家中醫藥研究所(原:國立中國醫藥研究所)
該期刊-上一篇 人參皂中的非主要皂成份引發離體大白兔陰莖海棉組織產生舒張反應
 

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