藥膳生脈鰱魚調節血脂和抗氧化延緩衰老等保健功效實驗研究

AN EXPERIMENTAL STUDY ON THE EFFECT OF SHENGMAILIANYU ON BLOOD-LIPID REGULATION AND ANTI-OXIDATION IN MICE

為了研究藥膳生脈鰱魚在調節血脂和抗氧化延緩衰老方面的保健作用，並探討以藥膳形式進行飲食保健可能性。將生脈鰱魚摻和到飼料中飼養實驗性高血脂鼷鼠30 天，測定血清總膽固醇（TC ）、甘油三酯（TG ）、高密度脂蛋白膽固醇（HDL-c ）、低高密度脂蛋白膽固醇（LDL-c ）等指標；另用生脈鰱魚摻和到飼料中飼養實驗性衰老鼷鼠40 天，測定血清及肝的超氧化物歧化　（SOD ）活力、肝的谷胱　　過氧化物　（GSH-Px ）活力、總抗氧化（T-AOC ）能力以及過氧化脂質（LipOperoxide ）含量。而發現生脈鰱魚可以明顯降低高血脂鼷鼠的 TC 、TG 、LDL-c ，升高HDL-c ，改善鼷鼠的動脈硬化指數（AI ）；生脈鰱魚可明顯提高衰老鼷鼠血清和肝的 SOD 活力，肝的 GSH-Px 活力、T-AOC 能力，降低肝 LPO 含量。高劑量組血清、肝 SOD 活力、肝GSH-PX 活力、中高劑量組肝 T-AOC 能力均顯著高於生脈飲組，高劑量組 LPO 含量則已顯著低於生脈飲組。結論: 生脈鰱魚具有一定的調節血脂和抗氧化延緩衰老作用，以藥膳的形式能夠達到相應的保健作用。To assess the health promotional capacity of the health formulation shengmailianyu (生脈鰱 魚 ) and substantiate its medicinal justification of being formulated as a medicinal meal, its effects on blood-lipid regulation and anti-oxidation were studied. Hyperlipidemia was induced in mice which were then administered varying doses of shengmailianyu in standard laboratory diet for 30 days. Control animals received the vehicle shengmaiyin. At the end of the treatment period serum total cholesteroal (TC), triglycerides (TG), high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C) were analyzed. In a second experiment sanesence mice were administered shengmailianyu in standard laboratory diet for 40 days. Serum and liver superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC) and lipoperoxide (LPO) were analyzed. The results indicated that shengmailianyu markedly decreased serum TC, TG and LDL-C while increasing HDL-C and improving the arteriosclerotic index (AI). It also significantly improved the values of SOD in the serum and liver, GSH-Px in the liver and T-AOC and reduced liver LPO. Although the effects of shengmailianyu on serum HDL-C, LDL-C and AI were insignificantly different from the vehicle shengmayin control, SOD in serum and liver, GSH-Px and T-AOC in the liver were significantly higher while liver LPO was lower following treatment with the high dose. Liver T-AOC was also lowered with the middle dose. In conclusion, shengmailianyu demonstrated blood lipid lowering and antioxidation effects in mice which support its being developed as a medicinal meal.