妊娠期及授乳期母鼠投與臺灣金線連水粗萃取物對新生兒的影響

EFFECTS OF CRUDE AQUEOUS EXTRACTS OF Anoectochilus formosanus Hayata ADMINISTERED TO PREGENANT AND LACTING RATS ON THEIR OFFSPRING

母鼠從妊娠第 7 天至產後第28 天，每天投與臺灣金線連水粗抽取物0.5 g/kg、2.0 g/kg及飲水。得到下列結果：1） 臺灣金線連水粗抽取物對母鼠的體重、攝食量沒有影響。2） 臺灣金線連水粗抽取物對母鼠的分娩、及新生兒的死產數、活產數、出生指數沒有影響。3） 臺灣金線連水粗抽取物對產後4 天新生兒的生存指數、及離乳指數沒有影響。4） 臺灣金線連粗水抽取物對新生兒的體重增加、攝食量沒有影響。5） 臺灣金線連水粗抽取物對新生兒的自發運動量、學習能力沒有影響。6） 目測觀察外型臺灣金線連水粗抽取物沒有致畸胎作用。以上結果顯示臺灣金線連水粗抽取物在2.0 g/kg/day 的劑量對母鼠、胎兒、新生兒沒有影響。Crude aqueous extracts of Anoectochilus formosanus (AAF) was administered orally to female rats at daily dose levels of 0, 0.5 and 2.0 g/kg from day 7 of gestation to postpartum day 28. Results obtained were as follows: 1) AAF did not affect the body weight gains, food intake in F0 dams. 2) Delivery status in F0 dams as well as number of stillborn pups, number of live pups and birth index were not affected by AAF. 3) AAF did not affect the viability index on postnatal day 4 and weaning index in F1 rats. 4) Body weight gain and food consumption were not affected in F1 rats given AAF. 5) AAF did not alter learning, spontaneous motor activity in both male and female F1 rats. 6) Teratogenicity of AAF could not be detected. The result indicate that no-effect dose level of AAF is 2.0 g/kg/day for dams, fetuses and offspring.