| 中文摘要 |
本文報告一位42 成女性，因長期嚴重使秘，每天J服用以決明于（二兩， 75 克）為主之方劑 達半年，便秘雄改善，然而大腸鏡檢查發現大腸黏膜顏色變d笨，如蛇皮狀，經活體病理按視，診斷早已結腸黑病變（Melanosis coli） ，我們懷疑與所舍的慧克（anthraquinone）類有闕，本文對anthraquinone 所致之結腸黑病變，及相關文獻作一介紹與討論。Juenmingzi (決明子), the seed of Cassia lora L., a wild plant grown in tropical Asian countries. are used in Chinese medicine to improve visual acuity. In the classical Chinese medicinal pharmacopeia 'The Essential Medica' it is described as follows: 'The flavor is bitter-sweet and salty. It acts on liver channel, treats the illnesses caused by attack of wind and heat and improves visual acuity'. Translated into modern pharmacological terms, these may represent antiinflammatory, hypotensive, and laxative effect. Even though the mechanism of its laxative effect remain unknown, we suspect that it is related to the anthraquinone contained in the seed of Cassia lora L. The present article reports the case of a 40-year-old female who took a Chinese prescription in which the main drug was Juemingzi (75 g per day) for 6 months to relieve the chronic and severe constipation. The condition improved as a result, However, melanosis coli was diagnosed by colon fibroscopy and biopsy. It is inferred that the melanosis coli was related to the anthraquinone content in Juemingzi. The case is reported along with a review of related literature. |
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