| 中文摘要 |
本實驗主要探討臺灣金線連水粗萃取物連續經口投與90天對大鼠的毒性作用。臺灣金線連水粗萃取物使用的劑量為每天投與0.5g/kg或2.0g/kg。雄性大鼠2.0g/kg組體重減輕。血液學檢查：雌性大鼠2.0g/kg 組出現中性球減少情形。血清生化學檢查：雌性大鼠2.0 g/kg 組的乳酸去氫活性及鈣、磷濃度下降。尿液分析：雄性大鼠2.0 g/kg 組出現輕微酮尿。臟器重量：雌性大鼠2.0 g/kg 組的腦下垂體、腎臟、肝臟增重，子宮減重，但並無實質上的病理組織變化。大鼠長期投與臺灣金線連水粗萃取物，安全劑量在0.5g/kg 以下。The 90-day repeated oral dose toxicity study of a crude aqueous extracts of Anoectochilus formosanus Hayata (AAF) was evaluated in rats. AAF was conducted at once-daily doses of 0, 0.5 and 2.0, g/kg. Inhibition of body weight gain was noted in the male group at 2.0 g/kg. In hematology, decreased amount of segmented neutrophil was observed in females of the 2.0 g/kg dose groups. In blood chemistry, a decrease in lactate dehydrogenase activity was observed in females of the 2.0 g/kg dose group. In addition, females given 2.0 g/kg showed a slight decrease in calcium and phosphorus levels. Urinalysis showed a slight increase in ketones in males of the 2.0 g/kg dose group. Increases in weight of pituitary, liver and kidney in the females of 2.0 g/kg dose group were observed, with no histopathological changes. In conclusion, the toxicological no-observed levels in rats were thought to be 0.5 g/kg or below. |
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