Using the Ms-G2 strain of the human hepatoma cell line that had been integrated with hepatitis-B viral gene, we screened 34 Chinese herbal drugs for their anti-hepatitis-B activity. The results showed that the four simple herbs Citri Leiocarpae Exocarpium, Scutellariae Radix, Amomi Rotundi Fructus and Artemisiae Capillaris Herba possessed anti-hepatitis-B surface antigen activity at 200 ug/mL. The inhibitory activities were 37.5, 41.3, 28.9 and 21.9% respectively. At 200 ug/mL, Zizyphi Fructus possessed anti-hepatitis-B surface antigen and e antigen activity, with inhibitory activities of 35.2 and 26.1% respectively. The other 29 Chinese herbal drugs did not possess anti-hepatitis-B activity at 200 ug/mL.