中藥抗B型肝炎病毒之篩選

Screening on the Anti-Hepatitis B Virus of Chinese Medicine Drugs

以具有B型肝炎病毒因體嵌入其內之人類肝癌細胞株MS-G2，進行34種中藥抗B型肝炎病毒之篩檢。結果顯示陳皮、黃芩、白豆蔻及茵陳等四個單味藥，在200 ug/ml時具有抑制B型肝炎病毒表面抗原(HBsAg)之作用。其抑制百分比分別為37.5、41.3、28.9及21.9%。紅棗具有抑制B型肝炎病毒表面抗原及e抗原之作用，其抑制百分比分別為35.2及26.1%。其餘29種中藥，在200 ug/ml時不具有抑制B型肝炎病毒之作用。

Using the Ms-G2 strain of the human hepatoma cell line that had been integrated with hepatitis-B viral gene, we screened 34 Chinese herbal drugs for their anti-hepatitis-B activity. The results showed that the four simple herbs Citri Leiocarpae Exocarpium, Scutellariae Radix, Amomi Rotundi Fructus and Artemisiae Capillaris Herba possessed anti-hepatitis-B surface antigen activity at 200 ug/mL. The inhibitory activities were 37.5, 41.3, 28.9 and 21.9% respectively. At 200 ug/mL, Zizyphi Fructus possessed anti-hepatitis-B surface antigen and e antigen activity, with inhibitory activities of 35.2 and 26.1% respectively. The other 29 Chinese herbal drugs did not possess anti-hepatitis-B activity at 200 ug/mL.