Eight Chinese herbs commonly used as antinflammatory drugs in traditional Chinese medicine were selected for immunopharmacological activity test. Human mononuclear cells (HMNC) from peripheral blood were used as target cells. Ethanolic extracts of the Chinese herbs were added into HMNC cultures. Subsequent, cell proliferation was determined by ?鯨-thymidine uptake. the results indicated that two out of eight ethanolic crude extracts of chinese herbs (Nothapodytes foetida and Piper futokadsura) suppressed HMNC proliferation. It is unlikely that cytotoxicity was involved, because no cell deaths were observable. the inhibitory mechanisms may involve the blocking interleukin-2 (IL-2) and interferon-γ (IFN-γ) production. Since both ethanolic crude extracts suppressed IL-2 and IFN-γ production of HMNC in a dose-dependent manner, Therefore, it is suggested that immunomodulatory agents are contained in N. foetida and P. futokadsura. Plans are underway for the isolation of pure compounds from these Chinese herbs and the elucidation of their mechanisms of action.