月旦知識庫
  1. 熱門:
 
首頁 臺灣期刊   法律   公行政治   醫學   財經   社會學   教育   其他 大陸期刊   核心   非核心 DOI文章
查看詳細全文
篇名
中草藥對於細胞性免疫反應影響之評估(Ⅲ)
並列篇名
Evaluation of Chinese Herbs that Affect the Cell-mediated Immunity(3)
作者 楊乃先周正仁林麗純蔡維人郭育綺
中文摘要
中草藥在我國已被臨床中醫師及民間廣泛運用,但目前仍缺乏有效科學數值以證實其療效,本篇論文即針對民間常用之消炎、止痛、止咳和治風濕等八種中草藥當材料,以人類單核球細胞(Human mononuclear cells)為標的細胞,藉以瞭解這些中草藥其療效與人體免疫反應間之關係。實驗中,我們以乙醇進行天然物的粹取,所得之粗粹取物與人類單核球細胞共同培養,經過三天以3H-thymidine 標識去氧核糖核酸合成,由此可知中草藥之粗粹取物對於人類單核球細胞生長的影響。結果顯示,在八種具消炎、止痛等功效之中草藥內,其中兩種(青脆枝及風藤)對於人類單核球細胞生長具有抑制作用,此外,它們也會抑制第二介白質(Interleukin-2)和丙種干擾素(Interferon- γ)的分泌。這些實驗結果符合中草藥之作用,未來我們將進一步純化其天然物,並探討其作用機轉。
英文摘要
Eight Chinese herbs commonly used as antinflammatory drugs in traditional Chinese medicine were selected for immunopharmacological activity test. Human mononuclear cells (HMNC) from peripheral blood were used as target cells. Ethanolic extracts of the Chinese herbs were added into HMNC cultures. Subsequent, cell proliferation was determined by ?鯨-thymidine uptake. the results indicated that two out of eight ethanolic crude extracts of chinese herbs (Nothapodytes foetida and Piper futokadsura) suppressed HMNC proliferation. It is unlikely that cytotoxicity was involved, because no cell deaths were observable. the inhibitory mechanisms may involve the blocking interleukin-2 (IL-2) and interferon-γ (IFN-γ) production. Since both ethanolic crude extracts suppressed IL-2 and IFN-γ production of HMNC in a dose-dependent manner, Therefore, it is suggested that immunomodulatory agents are contained in N. foetida and P. futokadsura. Plans are underway for the isolation of pure compounds from these Chinese herbs and the elucidation of their mechanisms of action.
起訖頁 179-188
關鍵詞 人類單核球細胞青脆枝風藤第二介白質丙種干擾素HMNCNothapodytes foetidaPiper futokadsuraProliferationIL-2IFN-γ
刊名 中醫藥雜誌  
期數 199909 (10:3期)
出版單位 衛生福利部國家中醫藥研究所(原:國立中國醫藥研究所)
該期刊-上一篇 劉完素婦科學術思想之研究
該期刊-下一篇 蒿屬植物劉寄奴之本草學考察
 

新書閱讀



最新講座


優惠活動




讀者服務專線:+886-2-23756688 傳真:+886-2-23318496
地址:臺北市館前路28 號 7 樓 客服信箱
Copyright © 元照出版 All rights reserved. 版權所有,禁止轉貼節錄