Since the discovery of Coxsackieviruses in 1948, the hand foot mouth diseases are happened in 1957 both in New Zealand and Canada as caused by Human Coxsackieviruses A5 and A16,a nd this disease appear in Mainland China first in Shanghai in 1981 then occured in different part of this country. In 1997 and 1998 such virus infection also occurred in Taiwan area. Until recently, no effective drug are available for the treatment of this virus infection. However, different kinds of traditional herbal drugs are used in mainland China clinically for the symptoms caused by this virus infection according to the Chinese medicine principles. The drug used are Banlangen and Dagingye (root and leaf of Isatis indigotica Fort), Huangqin (sutellariae baicalensis Georgi), Huanglian (Coptis chinesis Franch), Chaihu (Bupleurum Chinese DC.), Jinyinhua (Lonicera japonica Thumb.), Liangiao (Forsythia suspensa Thumb.), Tufuling (Smilax glabra Roxb.), Gancao (Glycyrrhiza uralensis Fisch). Thus the clinical efficacy should be evaluated by clinical trial methodology.