抑制人類肝癌細胞株乙型肝炎表面抗原分泌的天然物研究

Inhibition of Hepatitis B Surface Antigen Secretion on Human Hepatoma Cells Components and Derivatives from Natural Product

乙型肝炎在國人中廣泛流行，帶原者罹患、肝硬化及肝癌的比率很高。而肝癌病息的死亡率高居台灣癌病死亡率前茅。雖然注射乙型肝炎疫苗能幫助改善乙型肝炎的罹患率，但並非最徹底有效的方法。迄今對帶原者或慢性肝炎之患者，一般多用支持療法。目前非常缺乏有效且副作用小的藥物。所以發展能治療或預防乙型肝炎的藥物是一件十分重要的工作。

Liver disease is one of the major problems cause death among Chinese people. Investigation shows that hepatitis B surface antigen (HBsAg) carriers have more coincidence toward the development of hepatocellular carcinoma. Immunization against hepatitis B virus has helped somewhat in preventing chronic infection cases, but still not enough to solve this problem. Right now there are not many drugs available to treat these disease. Therefore, new drugs to eradicate hepatitis B virus in chronic carriers are needed.