In this study, we evaluated the clinical efficacy of long-term administration of Jia-Wei-Xue-Fu-Zhu-Yu-Tang (JWXZT) on the hyperlipidemic patients. We detected the serum levels of cholesterol, triglyceride, HDL-C, Apo Al and Apo B as the therapeutic index, the serum levels of sGOT, sGPT, BUN, creatinine, blood sugar, as the index of side effects. JWXZT relieved symptoms such as lumbago, weakness of the lower limbs, insomnia, numbness of the limbs and fatigue. JWXZT decreased the serum levels of C, TG and Apo A1 increased the serum levels of HDL-C and Apo B, and increased the ratio of Apo A1/Apo B after 8-week treatment, but with no statistical significance. JWXZT increased the serum level of Apo Al and the ratio of Apo A1/Apo B, decreased the serum level of Apo B after 12-week treatment. JWXZT did not affect the blood, liver and kidney functions alter long-term treatment. These results suggest that the hypolipidemic effect of JWXZT may be related to the inhibition of the accumulation of blood lipids through promoting blood circulation and removing blood stasis, or the increase in the serum level of HDL-C.