A supercritical fluid extraction (SFE) method was used for the extraction of bioactive compounds magnolol and honokiol in Magnoliae Cortex, as well as schizandrin and gomisin A in Schizandrae Fructus. In this study, the extraction condition used were 40 and 50 ℃, at 3000, 3500 and 4000 psi, respectively. Meantime, entrainers such as n-hexane, acetone and ethanol were added in the extraction. All extracts were assayed with HPLC. The results showed that magnolol and honokiol had the highest extraction yield when extracted at 50 ℃ and 4000 psi, but the yield was still far lower than the extraction by reflux with methanol. The entrainers did not increase the extraction yield to any significant extent. The optimum condition for extraction of schizandrin and gomisin A from Schizandrae Fructus was at 40 ℃ and 4000 psi. Schizandrin had approximately 60% extraction rate and gomisin A had an extraction rate arround 40% as compared to the methanol extraction. The use of entrainers did not improve the extraction yields of schizandrin and gomisin A.