瘀血症候群之科學觀解釋及袪瘀血劑的藥理學上之效果

Scientific Analysis of ＂Oketsu＂ (Blood Stagnant) Syndrome and Pharmacological Effects of Anti-Oketsu Drug

所謂瘀血之術語就是血液循環的障礙或血液停滯的意思。在1982 年我們將瘀血症候群的診斷基準使用多變量分析的手法加以提倡。根據此診斷基準（寺澤之基準）把瘀血症候群做了科學觀解釋。我們所做的研究成果摘要如下：1.瘀血症候群於眼放結膜微小循環的特性為明白瘀血症候群之微小循環的特性之目的，就20 位患者及35 位自願者使用影像的顯微鏡加以檢討。根據寺澤的瘀血症候群診斷基準，將這些對象分類為非瘀血群、輕度瘀血群、重度瘀血群三群。其次，這些三群和異常所見之間的關連性做了統計學上的解析。其結果顯示血管內的泥狀化現象或血液停滯所伴隨的血管內紅血球聚集瘀血病態呈現有意義的相關性。並且瘀血症候群與血管的蛇狀樣彎曲、狹小化、微小動脈瘤及血管新生都呈現有意義的相關性。此等眼結膜的異常所見，已有報告指出在動脈硬化症或糖尿病亦能見到。然而根據本研究，這些異常所見也會在無此種疾患的情況下被觀察到。本研究所謂瘀血症候群是從經驗中被認識的病態，有明顯具體的微小循環障礙來思考。

The term of 'Oketsu' refers to a state of insufficient blood-circulation and blood stasis. In 1982, we presented a diagnostic criteria on this syndrome by using multivariate analysis. According to this criteria ( TERAS A W A's Criteria ) . We have investigated the scientific aspects of this syndrome. The summary of our works are as follows: 1. The characteristics of the microcirculation of bulbar conjunctiva in 'Oketsu' syndrome In order to elucidate the characteristics of microcirculation in 'Oketsu' ( blood stagnant ) syndrome, 20 patients and 35 volunteers were evaluated by using a videomicroscope system. According to 'Terasawa' diagnostic criteria, patients and voluteers were classified into 3 groups : non-'Oketsu', mildly affected and severely affected with 'oketsu' syndrome. Then the correlations between the 'Oketsu' state and the presence of abnormal findings were analyzed statistically. The results showed that intravascular erythrocyte agglutination associated with sludging and/or stasis of blood significantly correlated with the 'Oketsu' synduome. This syndrome was also correlated with such aruchitectural changes as meandering, narrowing, microaneuisma and proliferation of microvessels. These abnormal findings in bulbar conjunctiva have been reported in arteriosclerotic and diabetic diseases; however, this investigation suggested that these abnormalities also appear without such diseases. It is thought that this study porvides the empirical concept of the 'Oketsu' syndorme with concrete scientific evidence regarding the abnormalities of microcirculation.