北高雄地區幽門螺旋桿菌感染與消化性潰瘍之現狀

Current Status of H. Pyloric Infection and Peptic Ulcer in North Kaohsiung Area

目的：幽門螺旋桿菌（H. pylori）感染在消化性潰瘍致病機制之角色非常地重要。吾人希望多瞭解過去醫療資源較不足的北高雄地區幽門螺旋桿菌感染與消化性潰瘍之現況。方法：吾人以回顧方式分析義大醫院164 位經內視鏡檢查證實為消化性潰瘍患者之臨床記錄以及有關項目之問卷所得，再加以分析、統計。結果：胃潰瘍、十二指腸潰瘍、以及胃潰瘍合併十二指腸潰瘍之幽門螺旋桿菌感染率分別為43.69%、53.19%、以及63.64%（p < 0.05）。感染幽門螺旋桿菌之胃潰瘍患者中以O型血者較多（p < 0.05）﹔感染幽門螺旋桿菌之十二指潰瘍患者中以B型血者較多（p < 0.05）。結論：由於特殊之人文、地理條件，北高雄地區消化潰瘍有特異之臨床表現。多瞭解臺灣各地區消化潰瘍之狀況對預防醫學會有所助益。

Objectives: H. pylori infection plays an important role in the pathogenesis of peptic ulcers. We want to know current status of H. pylori infection and peptic ulcer in the northern Kaohsiung area. Methods: We analysed clinical records and questionnaires retrospectively of 164 outpatients (male: 86; female: 78) at E-Da Hospital. The patients suffered from peptic ulcers proven by both endoscopy and CLO test. Results: H. pylori infection rates of gastric ulcer, duodenal ulcer, and gastric ulcer complicated with duodenal ulcer were 43.69%, 53.19%, and 63.64%, respectively (p < 0.05). In addition, the relative ratios of male to female patients with positive tests were 1.25, 1.5, and 1.1, respectively. Among gastric ulcer patients, those with blood-type O suffered more from H. pylori infection (p < 0.05). However, among duodenal ulcer patients, those with blood-type B suffered more from H. pylori infection (p < 0.05). Among gastric and duodenal ulcer patients, those of Hakka ethnicity suffered more from H. pylori infection (p < 0.05). Among gastric and duodenal ulcer patients, there was no correlation between H. pylori infection and smoking, drinking tea, or non-steroid anti-inflammatory drug usage. However, there was a correlation between H. pylori infection and coffee usage (p < 0.05).Conclusions: Due to specific geographic and cultural conditions, there could be distinctive presentations of peptic ulcers in the north Kaohsiung area. Better understanding of peptic ulcer status in this part of our country could be meaningful for better preventive medicine.