血液透析病患永久導管抗生素抗藥性感染的體外實驗

In-Vitro Study of a Permanent Catheter from a Hemodialysis Patient with Antibiotics Resistant Infection

處理血液透析病患之具有抗生素抗藥性的永久導管感染是很麻煩的。生物膜的黏附是其主要的問題，它使得有效的抗生素不能根除細菌。拔管並置換新導管最常被建議採用。本體外實驗檢驗一懷疑被生物膜黏附的導管，在增加抗生素濃度及浸潤時間的情況下細菌的反應。結果顯示，即使在高濃度抗生素及長達48小時浸潤下，細菌仍無法被根除。所以對上述感染，在血液透析前或血液透析中給予抗生素仍然無效。

Permanent catheter related infections with antibiotics resistance in hemodialysis patients are troublesome. Bilofilm coating is the major problem. The bacteria can not be eradicated by sensitive antibiotics due to biofilm. Removal of the catheter and replacement with a new one is always recommended. This in-vitro study examined the permanent catheter, which was clinically suspected with biofilm coating, with increasing the antibiotics immersion concentration and time. The result of this study showed, even with high concentration of antibiotics and 48 hours of immersion time, the bacteria still could not be eliminated. Giving the antibiotics Preor intra- dialysis is ineffective in the above situation.