1998年彰化地區人民B型肝炎與C型肝炎感染現況之調查

A County-Wide Survey of HBV and HCV Infection in Chang-Hua Habitants in 1998

本研究之目的是為了測定彰化地區居民血清中B型肝炎病毒表面抗原（HBsAg）、B型肝炎病毒表面抗原抗體（HBsAb）、以及C型肝炎病毒抗體（Anti-HCV）的盛行率。同時，血清中天門冬胺酸轉胺酶（AST）、丙胺酸轉胺酶（ALT）以及甲型胎兒球蛋白（AFP）亦被檢測。於7412位自願受檢者中，HBsAg、HBsAb、Anti-HCV、異常之AST、異常之ALT以及異常之AFP的盛行率分別是15.7%、60.5%、3.0%、7.7%、9.1%以及0.8%，只有0.4%的受檢者同時具有HBsAg以及Anti-HCV。男性血清中HBsAg以及Anti-HCV之盛行率比女性高，而HBsAb則相反。血清中Anti-HCV陽性者，其血清中異常AFP值、異常ALT值或是異常AST值之發生率都比血清中HBsAg陽性者高。血清中Anti-HCV陽性率隨著年齡增加而增加，但是HBsAg陽性與年齡之間並無關聯。在6547位有住址可查的受檢者中，以其所居住之鄉鎮來區分，各有9個鄉鎮超過B型肝炎病毒以及C型肝炎病毒之台灣平均感染率。

The purpose of this study was to determine the sero-prevalence of HBsAg, Anti-HBsAb, and Anti-HCV antibody among residents in Chang-Hua area. Serum GOT, GPT, and AFP were also tested. Of 7412 voluntary examined persons, the prevalence of HBsAg. Anti-HBsAb, Anti-HCV antibody, and abnormal serum ALT, AST, and AFP was 15.7%, 60.5%, 3.0%, 7.7%, 9.1%, and 0.8%, respectively. Only 0.4% of the examined persons carried both HBsAg and Anti-HCV antibody. The prevalence of serum HBsAg and Anti-HCV antibody was higher among men than women. However, the prevalence of Anti-HBsAb was higher in women. The prevalence of abnormal serum AFP, ALT, or AST value for the Anti-HCV seropositive persons were all higher than HBsAg carriers. The seropositive rate of Anti-HCV increased with age, but there was no association between HBsAg and age. Among 6547 examined persons whose address could be traced, classified by villages and towns they lived,the infection rate exceeded the average of Taiwan in 9 villages for HBV and 9 villages for HCV, respectively.