Over a past few years, a number of food safety affairs have affected Taiwan and consumer awareness of food safety and health raises. Government as well as public has concerned pesticides residues in vegetables and fruits for a long time. Development of a quick multi-residue analysis is a critical issue for monitoring pesticide residues due to versatile groups and new generations of pesticides. QuEChERS, a new sample-preparation method including only three steps, homogenization, extraction, and clean-up, makes analysis quick, easy, efficient, and safe. High selectivity and sensitivity of tandem mass spectrometry coupled with gas or liquid chromatography ensures the quantification and qualification of pesticide multi-residue analysis. This article reviews the application of QuEChERS and tandem mass spectrometry in multi-residue analysis of pesticide in vegetables and fruits.