Objectives: The aim of this study is to establish useful design strategies for health Information designers when planning and designing healthcare media for new immigrants. Methods: The study is implemented in six stages, namely, a focus group interview, the development of testing media, reliability and validity tests, a questionnaire survey, pre-post knowledge tests, and a usability survey. Results: The results suggest that the key challenges for immigrant mothers when caring for their children’s health relate to six factors, namely language, confidence, knowledge, culture, how to take care, and the use of healthcare media. The findings indicate that both leaflet intervention and website intervention are effective and there is no significant difference between them; furthermore, the criteria new immigrants use to evaluate healthcare media can be analysed in terms of the quality of the content, appearance, and process. Conclusions: The study concludes that efforts to assist new immigrants to take care of their children’s health by applying healthcare media are still at an early stage of development. Further study is needed to identify which of the characteristics of immigrant users impact their ability to learn about health information in order to incorporate these into an effective health intervention medium that optimises information systems.