由含羞草根部得到兩個新的二萜類抗菌成分

Two New Antimicrobial Diterpenoids from the Roots of Mimosa pudica

從含羞草根部分離得到兩個新的二萜化合物，命名為19-O-trans-feruloyl-labd-8(17)-en-15,19-diol (1) and 19-O-[(E)-3’,4’-dimethoxy cinnamoyl]-labd-8(17)-en-15,19-diol (2)。化合物1-2對酵母菌和細菌具有抗菌活性，對厚皮馬拉色菌的抗菌活性最強，其次為白色念珠菌和金黃色葡萄球菌，抑菌圈在12-16 毫米的範圍內。

From the root of Mimosa pudica L. (Fabaceae), two new diterpenoids, named 19-O-transferuloyl- labd-8(17)-en-15,19-diol (1) and 19-O-[(E)-3’,4’-dimethoxy cinnamoyl]-labd-8(17)-en- 15,19-diol (2) had been isolated. Their structures were determined by analysis of spectroscopic data, including 1D and 2D NMR. Compounds 1-2 showed antimicrobial activity against two yeast and two bacteria tested. The strongest activity was observed against Malassezia pachydermatis, followed by Candida albicans and Staphylococcus aureus in the range of 12-16 mm.