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| 篇名 |
Validated HPTLC Method for the Determination of Two Novel Steroids in Bulk and Pressurized Metered-Dose Preparations
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| 作者 |
Dave, Hiral N. (Dave, Hiral N.)、Makwana, Ashlesha G. (Makwana, Ashlesha G.)、Bhatt, Chaitanya (Bhatt, Chaitanya)、Pundarikakshudu, Kilambi (Pundarikakshudu, Kilambi) |
| 中文摘要 |
A sensitive, accurate, precise and reliable HPTLC method has been proposed for determination of Ciclesonide and Fluticasone propionate - two widely used novel steroids in bulk as well as in pressurized metered dose preparations. Ciclesonide and Fluticasone propionate resolved well in toluene: ethyl acetate: formic acid (7: 3: 0.1 v/v/v) with respective Rf values 0.46 ± 0.004 and 0.43 ± 0.012 and could be scanned at 242 nm and 236 nm respectively. Linearity was observed in the range of 400 – 1100 ng band-1 for Ciclesonide and 200 – 1000 ng band-1 for Fluticasone propionate. The method was validated as per ICH guidelines and successfully applied for quantification of Ciclesonide and Fluticasone propionate in their commercial metereddose formulations. The method was found to be less time consuming as well as cost effective for routine analysis. |
| 起訖頁 |
177-185 |
| 關鍵詞 |
Ciclesonide、Fluticasone propionate、High performance thin layer chromatography、Pressurized metered-dose preparations、Respiratory disorders |
| 刊名 |
國際應用科學與工程學刊 |
| 期數 |
201109 (9:3期) |
| 出版單位 |
朝陽科技大學理工學院
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A New Method for Solving Sensitivity Analysis for Fuzzy Linear Programming Problems |
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Simultaneous Estimation of Esomeprazole and Domperidone in Combined Dosage Form by HPLC |
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