腫瘤的基因療法

各種診斷與治療模式有著不同的優點及限制，早期診斷與合併治療將是未來對於癌症治療的趨勢。本實驗開發整合近紅外螢光與核子醫學影像之多功能奈米造影及光熱治療之藥物傳輸載體。多功能奈米微胞可包覆近紅外螢光染劑，作為近紅外螢光腫瘤造影劑，同時可將奈米微胞標誌放射性同位素，以單光子射出電腦斷層（SPECT）造影來監測藥物傳輸與載體於活體內分佈的狀況，藉此可合併近紅外螢光與核醫影像來早期診斷癌症。另外，本多功能奈米載體同時具備癌症光熱治療的能力。未來可合併包覆化療藥物，放大癌症高溫治療後的合併化學治療的毒殺效果。

Multifunctional micelles loaded with the near-infrared (NIR) dye and labeled with the radionuclide has been developed to provide multi-modalities for NIR fluorescence and nuclear imaging and for photothermal therapy (PTT) of cancer. The NIR dye, IR-780 iodide, allowed the micelles to have dual functions in cancer NIR imaging and PTT. The radionuclide-labeled IR-780 micelles enabled imaging by NIR fluorescence and by microSPECT to guide the delivery of drugs, and to monitor in real-time the tumor accumulation, intratumoral distribution, and kinetics of drug release, which serve as basis of specific photothermal injury to the targeted tissue. The radionuclide-labeled IR-780 micelles offer multifunctional modalities for NIR fluorescence and nuclear imaging and for PTT of cancer. In addition, the multifunctional micelles could be loaded with chemotherapeutic drug for the synergistic combination of chemotherapy and photothermal therapy in the future.