薑黃素微乳液之製備及其在超音波影響下對口腔鱗狀上皮細胞癌細胞株之抑制作用

健康相關生活品質已普遍成為臨床重要之結果評量，特別可用於了解中風對患者個人主觀感受與需求之影響。中風常致患者產生認知或語言所造成之溝通困難，使得評量不易或無法掌握患者受疾病衝擊之情形。本研究乃是驗證中風病人與其主要照護者對於患者的健康相關生活品質評量之關連程度，以探討利用代理人評量（proxy assessments）來反映中風患者受疾病影響及其健康相關生活品質之可行性。在台灣，社會與家庭皆強調倫理與親人照顧的重要性，以及對聘用外籍看護之政策開放，促使照護者陪伴或參與患者因中風以來的長期就醫過程，是台灣復健醫療中極為普遍但卻異於國際經驗的特有現象，非常適合藉此探究代理人評量之議題。本研究總共招募19 對中風患者及其配對之主要照護者，共計38 位受試者，其照護者與中風患者於中風衝擊量表之評量結果，高達8 項中有7 項的分項測驗皆達普通至極高程度（ICC 值範圍：0.39 至0.81, p <0.05 ）之ㄧ致性，顯示照護者評量可作為中風患者健康相關生活品質評量之代理選擇。

To monitor the change of stroke survivors, the health-related quality of life (HRQoL) has become an important outcome measure. The disease-specific HRQoL measures such as the Stroke Impact Scale (SIS) can be used to reflect the impact of disease features on the patients' subjective perspectives. Nevertheless, the stroke survivors are commonly restricted by the communication or cognitive dysfunction and consequently have difficulties to complete the ratings of HRQoL measures. Proxy assessment was considered as a potential surrogate corresponding to self-report of patients' HRQoL levels. This study was to investigate the consistency between the proxy assessments and self-reports. Totally 19 stroke of the stroke-specific HRQoL patient-caregiver dyads completed the stroke impact scale (SIS). The ICC values computed for the SIS scores rated by patients and caregivers were fair to high level. These findings suggested the proxy assessments can be a good choice for clinical practitioners and researchers to detect the patients' subjective concerns and needs due to disease impact of stroke.